De Bonis Michele Professore AssociatoMedicineMEDS-13/C

PROFESSIONAL EXPERIENCE

– Chief of Cardiac Surgery, Innovation and Research, San Raffaele University Hospital, Via Olgettina 60, 20132 Milan, Italy (2017-present)

– Associate Professor of Cardiac Surgery at “Vita e Salute” San Raffaele University Medical School, Milan, Italy (2016-present)

– Director Training School in Cardiac Surgery, “Vita e Salute” San Raffaele University Medical School, Milan, Italy (2017-present)

– Head of the “Heart failure surgery Unit and Mechanical Circulatory Support Programme” of the Department of Cardiac Surgery, San Raffaele University Hospital, Milan, Italy (2009-present)

– Visiting Professor of Cardiac Surgery, Plymouth NHS Trust, Plymouth, United Kingdom (2017-present)

– Visiting Professor of Cardiac Surgery, Cardiovascular Research Unit, Faculty of Health Sciences, Cape Town University,  South Africa (2017-present)

– Contract Professor of Cardiac Surgery at “Vita e Salute” San Raffaele University Medical School, Milan, Italy (2008-2016).

– Contract Professor of Cardiac Surgery at the training School in Cardiac Surgery of “Vita e Salute” San Raffaele University Medical School, Milan, Italy (2007-2016).

– Contract Professor of Cardiac Surgery at the Nursing School of “Vita e Salute” San Raffaele University Medical School, Milan, Italy (2007-2016).

– Inventor of an original trans-catheter device for the percutaneous treatment of tricuspid regurgitation (Star-Tric System, European Patent Office number IT201700052909)

– Contract Professor at Politecnico of Milano within the Bioengineering PhD Programme

– Chairman of the Task Force on Mitral and Tricuspid Surgery of the European Association for Cardiothoracic Surgery

– Senior Staff Cardiac Surgeon (Research and clinical activity), Department of Cardiac Surgery, San Raffaele University Hospital Milan, Italy (2007- 2008).

– Staff Cardiac Surgeon (Research and clinical activity), Department of Cardiac Surgery

San Raffaele University Hospital, Milan, Italy (2000-2006).

Clinical responsibilities

Large experience as first operator in the surgical treatment of all kinds of adult cardiac disease. Mitral and tricuspid repair and mechanical circulatory  support (LVAD/BiVAD/TAH) represent areas of specific expertise. Minimally invasive and trans-catheter valve interventions, together with aortic valve repair are currently the fields of major clinical and scientific interest.

Since 2009 he has been responsible for the “Heart failure surgery Unit and Mechanical Circulatory Support Programme” of the Department of Cardiac Surgery, San Raffaele University Hospital, Milan, Italy.

After a training period spent as a Fellow on mechanical support systems at the German Heart Institute in Berlin, he started (in close collaboration with the  Cardiac Surgery Intensive Care Unit), a comprehensive program of mechanical circulatory support at San Raffaele Hospital in Milan. This program is currently consolidated and includes the use of paracorporeal systems (ECMO venous-arterial and veno-venous, LVAD/RVAD/BiVAD type Levitronix-CentriMag), partially implantable systems (Incor, Jarvik, HeartMate II and III, Heartware) and total artificial heart (CardioWest).

Currently approximately 100 patients/year are treated with an ECMO system in our Unit and about 100 patients received an LVAD as destination therapy. The experience in this field is confirmed by the role of “proctor” for implantation of the HeartMate II and III left ventricular assist system (Thoratec) covered from the year 2015.

He has obtained the following implantation certifications:

– SynCardia Total artificial heart phase I training (Germany 24th February 2012)

– HeartMate III Masterclass, National Research Cardiac Surgery Center (Astana, Kazakhstan,             June 30th-July 1st 2015)

National and international executive offices

Over the years, and more intensively since 2009, he has served in different roles  the European Society of Cardiology (ESC), the European Association for Cardiothoracic Surgery (EACTS), the American Heart Association (AHA), the Italian Society of Cardiac Surgery (SICCH) and the Heart Valve Society (HVS).

In particular he has been:

– Chairman of the Working Group on Cardiovascular Surgery of the European Society of Cardiology (2014-2016).

– Member of the “Acquired Cardiac Disease Domain” of the European Association for Cardiothoracic Surgery (2012-2016)

– Coordinator of the “ Committee for Guidelines and Position Papers” and member of the “Committee for the relationships with the European Association for Cardiothoracic Surgery” of the Italian Society of Cardiac Surgery (2014-2016)

– “Coordinator” (liaison) for Europe of the Leadership Committee of the Commission of the Council on Cardiovascular Surgery and Anesthesia of the American Heart Association (2015-2017)

As a member of the “Congress Programme Committes” (CPC) of the ESC, EACTS and HVS he has systematically participated in the organization of the related annual meeting scientific programs.

Guidelines of the European Society of Cardiology and Cardiac Surgery

He has been a member of “The Joint Task Force on the Management of Valvular Heart Disease of the European Society of Cardiology (ESC) and the European Association for Cardio-Thoracic Surgery (EACTS)”and he has participated in drafting the following European guidelines on valvular disease and infective endocarditis:

1) Authors/Task Force Members, Vahanian A, Alfieri O, Andreotti F, Antunes MJ, Barón-Esquivias G, Baumgartner H, Borger MA, Carrel TP, De Bonis M, Evangelista A, Falk V, Iung B, Lancellotti P, Pierard L, Price S, Schäfers HJ, Schuler G, Stepinska J, Swedberg K, Takkenberg J, Von Oppell UO, Windecker S, Zamorano JL, Zembala M; ESC Committee for Practice Guidelines (CPG), Bax JJ, Baumgartner H, Ceconi C, Dean V, Deaton C, Fagard R, Funck-Brentano C, Hasdai D, Hoes A, Kirchhof P, Knuuti J, Kolh P, McDonagh T, Moulin C, Popescu BA, Reiner Z, Sechtem U, Sirnes PA, Tendera M, Torbicki A, Vahanian A, Windecker S; Document Reviewers:, Popescu BA, Von Segesser L, Badano LP, Bunc M, Claeys MJ, Drinkovic N, Filippatos G, Habib G, Kappetein AP, Kassab R, Lip GY, Moat N, Nickenig G, Otto CM, Pepper J, Piazza N, Pieper PG, Rosenhek R, Shuka N, Schwammenthal E, Schwitter J, Mas PT, Trindade PT, Walther T.

Guidelines on the management of valvular heart disease (version 2012): The Joint Task Force on the Management of Valvular Heart Disease of the European Society of Cardiology (ESC) and the European Association for Cardio-Thoracic Surgery (EACTS).

Eur Heart J. 2012 Oct;33(19):2451-96

2) 2015 ESC Guidelines for the management of infective endocarditis: The Task Force for the Management of Infective Endocarditis of the European Society of Cardiology (ESC)Endorsed by: European Association for Cardio-Thoracic Surgery (EACTS), the European Association of Nuclear Medicine (EANM).

Authors/Task Force Members, Habib G, Lancellotti P, Antunes MJ, Bongiorni MG, Casalta JP, Del Zotti F, Dulgheru R, El Khoury G, Erba PA, Iung B, Miro JM, Mulder BJ, Plonska-Gosciniak E, Price S, Roos-Hesselink J, Snygg-Martin U, Thuny F, Tornos Mas P, Vilacosta I, Zamorano JL; Document Reviewers, Erol Ç, Nihoyannopoulos P, Aboyans V, Agewall S, Athanassopoulos G, Aytekin S, Benzer W, Bueno H, Broekhuizen L, Carerj S, Cosyns B, De Backer J, De Bonis M, Dimopoulos K, Donal E, Drexel H, Flachskampf FA, Hall R, Halvorsen S, Hoen B, Kirchhof P, Lainscak M, Leite-Moreira AF, Lip GY, Mestres CA, Piepoli MF, Punjabi PP, Rapezzi C, Rosenhek R, Siebens K, Tamargo J, Walker DM.

Eur Heart J. 2015 Nov 21;36(44):3075-128

He is a Task Force Member of the ESC Guidelines on Cardiovascular Diseases during Pregnancy and ESC Focused update on dual anti-platelet therapy

Position papers of the European Society of Cardiology

He also promoted and finalized the following important “position paper” on surgical and trans-catheter treatment of mitral regurgitation coordinating the activity of two Working Groups of the European Society of Cardiology (Cardiovascular Surgery and Valvular Heart Disease). This scientific contribution was deemed worthy of publication in the prestigious European Heart Journal:

– Surgical and interventional management of mitral valve regurgitation: a position statement from the European Society of Cardiology Working Groups on Cardiovascular Surgery and Valvular Heart Disease.

De Bonis M, Al-Attar N, Antunes M, Borger M, Casselman F, Falk V, Folliguet T, Iung B, Lancellotti P, Lentini S, Maisano F, Messika-Zeitoun D, Muneretto C, Pibarot P, Pierard L, Punjabi P, Rosenhek R, Suwalski P, Vahanian A, Wendler O, Prendergast B.

Eur Heart J. 2016 Jan 7;37(2):133-9

Fellowship of the European Society of Cardiology and American Heart Association

The scientific and organizational activities carried out for the European Society of Cardiology and American Heart Association have earned him the award of the title of Fellow of the European Society of Cardiology (FESC) and Fellow of the American Heart Association (FAHA).

Positions held in International Societies and Scientific Associations:

– Fellow of the American Heart Association (FAHA)

– Member of the SCIENTIFIC & CLINICAL EDUCATION LIFELONG LEARNING (SCILL) COMMITTEE, of the Council on Cardiovascular Surgery & Anesthesia (CVSA) of the American Heart Association for: 1) adult education, 2) program evaluation.

– Member of the Oversight Committee of the European Society of Cardiology for the Educational Programme “Awareness in Mitral Regurgitation”

– Fellow of the European Society of Cardiology (FESC)

– “European Liaison” of the Leadership Committee Commission of Council on Cardiovascular Surgery and Anesthesia of the American Heart Association

– Past-Chairman of the Working Group for Cardiovascular Surgery of the European Society of Cardiology

– Chairman of the Working Group for Cardiovascular Surgery of the European Society of Cardiology (2014-2016)

– Coordinator of the “ Committee for Guidelines and Position Papers” and member of the “Committee for the relationships with the European Association for Cardiothoracic Surgery” of the Italian Society of Cardiac Surgery (2014-2016)

– Member of the “Acquired Cardiac Disease Domain” of the European Association for Cardiothoracic Surgery (2012-2016)

– Secretary of the Nucleus of the Working Group for Cardiovascular Surgery of the European Society of Cardiology (2010-2014)

– Member of the Task Force of the Guidelines on Management of Valvular Heart Disease of the European Society of Cardiology and European Association for Cardiothoracic Surgery (Version 2012)

– Member of the Nucleus of the Working Group for Cardiovascular Surgery of the European Society of Cardiology

Membership in National and International Societies of Cardiology and Cardiac Surgery:

– Member of the “European Association for Cardiothoracic Surgery”

– Member of the American Heart Association

– Member of the European Society of Cardiology

– Member of the Italian Society of Cardiac Surgery

EDUCATION 

– Medical Doctor degree (110/110 cum laude), Catholic University of the Sacred Heart  Medical School, Rome, Italy (1993).

– United States Medical Licensing Examination (USMLE) Certification (1998).

– “Full registration” at the General Medical Council (United Kingdom) under the Medical Act 1983 in the Principal List of the register of medical practitioners (Registration No.: 4486077) (1998).

– Full time fellowship at the European Homograft Bank International Association, Bruxelles, Belgium (Director Prof. Y.A. Goffin) (1995-1996).

– Postgraduate Visiting Fellowships, Department of Cardiac Surgery, Onze Lieve Vrouw Clinic, Aalst, Belgium and Department of Cardiac Surgery, Brugmann University Hospital and Queen Fabiola University Hospital for Children, Bruxelles, Belgium (1995-1996)

– Postgraduate Visiting Fellowship, Department of Cardiothoracic Surgery, St. George’s Hospital, University of London, London, United Kingdom (Director Prof. T. Treasure) (August 1997).

– Specialist Registrar in Cardiothoracic Surgery, Department of Cardiothoracic Surgery, St. George’s Hospital, University of London, London, United Kingdom (1998-1999).

– Full Training in Cardiac Surgery (50/50 cum laude), Catholic University of the Sacred Heart Medical School, Rome, Italy. (1994-1999)

– Visiting Fellowship in mechanical circulatory support (ECMO, VAD, Total Artificial Heart), German Heart Institute, Berlin, Germany. (Director: Prof. R. Hetzer) (April-May 2008)

PRIZES AND AWARDS

– Honorable mention during the sixth edition of “Premio Medicine Prof. P. Petrone” for his MD thesis entitled “Non-pharmacological treatment of atrial fibrillation”. Potenza, Italy, December 2, 1995.

– National Award Ciociaria Medicine 2005. Fiuggi, January 22, 2005.

 

ACADEMIC QUALIFICATION

He has been teaching for many years at the Medical School, Nursing School and Training School in Cardiac Surgery of Vita-Salute San Raffaele University in Milan (Italy) in quality of:

–  Associate Professor of Cardiac Surgery at “Vita e Salute” San Raffaele University Medical School, Milan, Italy (since 2016).

– Contract Professor of Cardiac Surgery (SSD MED/23) at “Vita e Salute” San Raffaele University Medical School, Milan, Italy (since 2008).

– Contract Professor of Cardiac Surgery at the Nursing School of “Vita e Salute” San Raffaele University Medical School, Milan, Italy (since 2007)

– Contract Professor of Cardiac Surgery at the training School in Cardiac Surgery of “Vita e Salute” San Raffaele University Medical School, Milan, Italy (since 2007).

He has been mentoring the trainees of the training school in cardiac surgery and he has been giving lectures and elective courses in order to promote the comprehensive training of the medical students in the field of cardiac surgery. The satisfaction questionnaires filled out by the students systematically confirmed over the years the attitude to teaching with an interactive and engaging approach. He has been coordinating more than 20 thesis in Medicine and Nursing.

Lecturer at the European School for Cardiothoracic Surgery/EACTS Academy

Since 2003 he has been having intense lecturing and teaching activities at the European School for Cardiothoracic Surgery of Bergamo (Italy) and at the Academy of the European Association for Cardiothoracic Surgery in Windsor (Great Britain) (fundamental and advanced courses).

He has been promoting “wet-labs” on the surgical repair of the mitral and tricuspid valves which have been periodically held at the EACTS Academy.

In addition he has been leading similar courses during the 2015 and 2016 editions of the Congress of the European Association for Cardiothoracic Surgery in Amsterdam and Barcellona, respectively.

SCIENTIFIC QUALIFICATION

Extensive scientific experience in the field of adult cardiac surgery with specific reference to surgical and percutaneous techniques for mitral and tricuspid valve repair.

The scientific production is relevant (H index>20, number of citations >3000) and characterized by continuity over the years.

He has been giving more than 150 presentations, mainly at international congresses.

He has been co-editor of the following book on mitral valve repair:

– Edge-to-Edge Mitral Repair: From a Surgical to a Percutaneous Approach.O. Alfieri, M. De Bonis, G. La Canna. (editors). Springer International Publishing Switzerland 2015.

ISBN: 978-3-319-19892-7 (Print) 978-3-319-19893-4 (Online)

DOI 10.1007/978-3-319-19893-4_7

 

In addition he has been Author of 14 chapters in Cardiac Surgery textbooks (see references).

Funded peer-reviewed research projects:

– Progetto CCM (Centro Nazionale per la Prevenzione e il Controllo delle Malattie): Supporto extracorporeo cardiorespiratorio con ECMO (extracorporeal membrane oxygenation) in pazienti con scompenso cardiaco: miglioramento dell’outcome e prevenzione delle complicanze” (2008).

Partner: CNR Istituto di Bioimmagini e Fisiologia Molecolare, Milano

Funding: euro 500.000

Role: co-operating officer.

 

– Studio di superfici bioattive per l’ottimizzazione degli LVADs (Left Ventricular Assis Devices): BIOSUOVAD (bioactive surfaces for optimized LVAD). Project funded under the call for proposals for the testing of development initiatives, development of human capital and transfer of research results with direct impact on the Lombard territory issued by the Italian Interuniversity Consortium for Science and Technology of Materials (INSTM) on December 5, 2012 in implementation of the Agreement of cooperation signed between the Region of Lombardy and  the INSTM on November 13, 2012.

Duration: 15/5/ 2013-15/5/2015

Funding: euro 40.000

Role: Co-Investigator of the INSTM Research Unit San Raffaele Hospital

- 2023 – today       Principal Investigator

PNRR-MAD-2022-12376796 Project: “MAcklin effect, quantitative imaging analysis and CytoKine profiling to predict Lung frailty in ARDS (MACKLIN ARDS)”

Partners: AOU Cagliari, Anesthesia and Intensive Care Unit, Cagliari, Italy; AOR San Carlo Potenza, Division of Cardiac Resuscitation, Cardiovascular Anesthesia and Intensive Care, Potenza, Italy; AOU Pisana, Anesthesia and Intensive Care Unit, Pisa, Italy.

Funding: euro 980.000

Other roles

– Member of the Clinical Event Committee (CEC Committee) of the Surtavi Randomized Trial (TAVI versus Surgical aortic valve replacement in intermediate risk patients) (2014-present)

– Chairman of the “Adverse Events Safety Board” of the Prevent Study for the percutaneous treatment of tricuspid regurgitation with Tri-cinch (4-Tech) system (2013-present)

Associate Editor/Editorial Board Member of the following International Journals

– Associate Editor of the International Journal of Cardiology

– Member of the Editoral Board of the Interactive journal of cardiovascular and thoracic surgery, Annals of Cardiology and Cardiovascular Diseases, Heart, Lung and Vessels (previously  HSR Proceedings in Intensive Care and Cardiovascular Medicine).