Consolo Filippo Ricercatore a tempo determinatoMedicineING-IND/34 – Bioingegneria industriale

Ph.D.

 

Scientific career

- 2017-now: Assistant Professor. Faculty of Medicine and Surgery, Università Vita Salute San Raffaele, Milano, IT.

- 2017-now: Principal Scientist at the PAS Lab, San Raffaele Scientific Institute, Milano, IT.

Main Research Topic: Cardiovascular Clinical and Translational Research.

- 2010-2016: Post-doctoral Fellow. Dept. of Electronics Information and Bioengineering, Politecnico di Milano, Milano, IT.

Main Research Topic: Tissue and Organ Regeneration: Design and development of dynamic and miniaturized engineered systems (bioreactors and microfluidic platforms) for cell conditioning and functionalization.

- 2014: Research Fellow. SORIN Group Italia - Performance optimization of a blood heat exchanger for cardiopulmonary by-pass.

- 2013: Visiting Researcher. Biofluids Laboratory (Bluestein Lab), Biofluids Research Group, Dept. of Biomedical Engineering, Stony Brook University, NY, USA.

- 2010: PhD in Biomedical Engineering. Dept. of Mechanics, Bioengineering Division, Politecnico di Torino, Torino, IT.

Title of the Thesis: Computational Modelling and Bio-nanotechnologies: A Multidisciplinary Approach For The Design of Tissue Engineering Applications.

Tutors: Prof. Franco Maria Montevecchi, Prof. Alberto Redaelli, Prof. Umberto Morbiducci.

- 2009: Visiting PhD Student. Biomacromolecules Laboratory, Dept. of Chemistry, Università Alma Mater Studiorum of Bologna, Bologna, IT. Tutor: Prof. M.L. Focarete.

- 2008: Visiting PhD Student. Tissue Engineering Group (GREAT), Dept. of Physics, Faculdade de Ciências e Tecnologia, Universidade Nova de Lisboa, Lisbon, PT. Tutor: Prof J. Silva.

- 2007: II Level Master “Design Elements of Micro- and Nanotechnologies for Bioartificial Systems". Politecnico di Torino, Dept. of Mechanics, Bioengineering Division, Torino, IT.

- 2006: Master Degree in Biomedical Engineering. Dept. of Electronics Information and Bioengineering, Politecnico di Milano, Milano, IT.

Title of the Thesis: Design and development of an integrated computational model for the optimization of transport phenomena in a rotating hollow fiber bioreactor for artificial liver Tutors: Prof. Alberto Redaelli, Prof. Gianfranco Fiore.

- 2003: Bachelor Degree in Biomedical Engineering. Dept. of Electronics Information and Bioengineering. Politecnico di Milano, Milano, IT.

Title of the Thesis: Development of a computational tool for the analysis of intra coronary flow curves.

Tutors: Prof. Alberto Redaelli, Prof. Gianfranco Fiore. External Tutor: Dr. Massimo Lemma, Dept. of Cardiac Surgery, Ospedale L. Sacco, Milano.

 

Research Interests and Activities

- Cardiovascular Clinical and Translational Research

Design and development of innovative diagnostic tools for the prevention of post-operative adverse events in patients implanted with Mechanical Circulatory Support (MCS) devices. Research activities are pursued in collaboration with the Anesthesia and Cardiothoracic Intensive Care Unit, the Coronary Intensive Care Unit, and the Coagulation Service and Thrombosis Research Unit of the San Raffaele Scientific Institute (Prof. Alberto Zangrillo, Prof. Federico Pappalardo, Dr. Armando D’Angelo) in the framework of the Advanced Heart Failure and Mechanical Circulatory Support Program of the San Raffaele Scientific Institute.

Research activities combine different approaches and methodologies, including:

ž patient-specific evaluation of the ventricular hemodynamics

ž analysis of the MCS system operating conditions (log-files) and evaluation of the patient-device physiological interplay

ž study and evaluation of blood cells shear-mediated damage

ž in vivo characterization of shear mediated platelet activation and prothrombotic activity

ž patient-tailored optimization of antithrombotic therapeutic regimen

 

Research Grants

- 2015: Principal Investigator. CARIPLO Foundation Grant: Biomedical research conducted by Young Researchers (UniSR)

Project title: MicroVAD: A Microfluidic platform for understanding of the molecular basis of post-implant thrombosis In Ventricular Assist Device recipients: endothelial-cell platelet interactions at the ventricular-VAD interface.

Duration: 3 years

Budget: 249.500EUR

Partner: Sarver Heart Center, University of Arizona, AZ, USA (Prof. Marvin J Slepian).

- 2013-2015: Research Assistant. CARIPLO Foundation Grant (Politecnico di Milano)

Project Title: Evaluation of the thrombogenic risk: development of new approaches for the prediction of platelet activation and its minimization in artificial organs and prostheses.

Duration: 3 years

Budget: 300,000 EUR

Partner: Stony Brook University, Stony Brook, NY, USA (Prof. D Bluestein).

- 2010-2012: Co-investigator. Italian Ministry of University and Research Grant (Politecnico di Milano)

Project Title: Urinary bladder in vitro regeneration: mechanical stimuli effects during tissue maturation.

Duration: 3 years

Budget: 145,000 EUR.

Partners: Faculty of Veterinary Medicine, Università degli Studi di Milano; Department of Mechanics, Politecnico di Torino; Department of Industrial and Mechanical Engineering, Università degli Studi di Catania; Department of Mechanics and Industrial Technologies, Università degli Studi di Firenze.

- 2009-2011: Co-investigator. CARIPLO Foundation Grant (Politecnico di Milano)

Project Title: “Nano-Micro-Structured Polymeric Matrices For Engineered Cardiac Prototissues”

Duration: 3 years

Budget: 400,000 EUR

Partner: Faculty of Medicine, Universita' degli Studi del Piemonte Orientale (Prof. M Prat).

 

Awards

- European Society of Biomechanics (ESB): 2015 Best poster Award.

Dimasi A, Rasponi M, Consolo F, Valerio L, Fiore GB, Bluestein D, Slepian M, Redaelli A. Microfluidic emulators of ventricular assist device shear stress patterns. 21st Congress of the European Society of Biomechanics. 5-8 July 2015, Prague, Czech Republic.

- American Society of Mechanical Engineering (ASME): 2nd place in the PhD Student Competition - Poster presentation - Category: Biofluids and Imaging.

Consolo F, Caronna M, Montevecchi FM, Fiore GB, Redaelli A A CFD computational model for the optimization of transport phenomena in a rotating hollow fiber bioreactor for artificial liver. 2008 ASME-SBC, June 25-29 2008, Marco Island, FL (USA).

 

Major Scientific Collaborations

- Prof. Alberto Redaelli, Dept. of Electronics Information and Bioenginering, Politecnico di Milano: Design and development of numerical, computational, and experimental tools for the optimization (minimization) of the thrombogenic potential of MCS devices.

- Prof. Marvin J Slepian, Sarver Heart Center at the Univerisity of Arizona, Tucson, AZ, USA: Design and development of a microfluidic platform (Lab-on-Chip) for the evaluation of the thrombogenic potential associated with MCS fluid dynamics.

- Prof. Danny Bluestein, Biofluids Research Group, Dept. of Biomedical Engineering, Stony Brook University, Stony Brook, NY, USA: Design and development of numerical and experimental tools for the analysis of the thrombogenicity of mechanical blood recirculating devices and prostheses (Device Thrombogenicity Emulator, DTE).

- Prof. Claudius Mahr, University of Washington Medical Center, Seattle, WA, USA: Design and development of numerical and experimental tools for the analysis of the thrombogenic risk in MCS patients.

- Prof. Alice Tomei, Islet Immunoengineering Laboratory at the Diabetes Research Institute, Miami, FL, USA: Design and development of a microfluidic platform allowing conformal coating of Islets of Langerhans to be transplanted in diabetic patients.

 

Teaching

- 2017-now: Lecturer: Residency Program in Cardiac Surgery. Università Vita Salute San Raffaele, Milano, IT.

- 2016-now: Lecturer: Material Biocompatibility and Material Science and Technology. Bachelor Degree in Cardiovascular Physiopathology and Perfusion Techniques. Faculty of Medicine and Surgery. Università degli Studi di Pavia, Pavia, IT.

- 2016: Lecturer: Optimal design of blood contact devices - PhD Program in Bioengineering. Politecnico di Milano, Milano, IT.

- 2012-2016: Assistant Lecturer: Laboratory of Bio-fluid dynamics. Master Degree in Biomedical Engineering. Politecnico di Milano, Milano, IT.

- 2014: Invited Lecturer: Atlantis CRISP Summer School 2014 - Biomechanics for Cardiovascular Surgery. Politecnico di Milano, Milano, IT.

- 2012-2014: Invited Lecturer: Cellular therapies and tissue engineering. Master Degree in Medical Biotechnologies and Translational Medicine. Faculty of Medicine and Surgery. Università degli Studi di Milano, Milano, IT.

- 2009: Assistant Lecturer: Computer-aided design of biomechanical systems. Master Degree in Biomedical Engineering. Politecnico di Torino, Torino, IT.

- 2008: Assistant Lecturer: Computational Bio-fluid dynamics. Master Degree in Biomedical Engineering. Politecnico di Torino, Torino, IT.

 

Reviewer of:

- ASAIO Journal

- International Journal of Artificial Organs

- Artificial Organs

- Medical Engineering & Physics

- Acta Biomaterialia

- PlosOne

- Scientific Reports

 

Editorial Board:

- ASAIO Journal

 

Publications Complete List of Publication: Scopus

Scopus Author ID: 26634965600

List of Selected Publications

- Consolo F, Esposti F, Gustar A, De Bonis M, Pappalardo F. Log files analysis and evaluation of circadian patterns for the early diagnosis of pump thrombosis with a centrifugal continuous-flow left ventricular assist device. J Heart Lung Transplant. 2019 Apr 29. doi: 10.1016/j.healun.2019.04.008. [Epub ahead of print].

- Apostoli A, Bianchi V, Bono N, Dimasi A, Ammann KR, Moiia YR, Montisci A, Sheriff J, Bluestein D, Fiore GB, Pappalardo F, Candiani G, Redaelli A, Slepian MJ, Consolo F. Prothrombotic activity of cytokine-activated endothelial cells and shear-activated platelets in the setting of ventricular assist device support. J Heart Lung Transplant. 2019 Feb 18. doi: 10.1016/j.healun.2019.02.009. [Epub ahead of print].

- Selmi M, Chiu WC, Chivukula VK, Melisurgo G, Beckman JA, Mahr C, Aliseda A, Votta E, Redaelli A, Slepian MJ, Bluestein D, Pappalardo F, Consolo F. Blood damage in Left Ventricular Assist Devices: Pump thrombosis or system thrombosis? Int J Artif Organs. 2019 Mar;42(3):113-124. doi: 10.1177/0391398818806162.

- Consolo F, Sferrazza G, Motolone G, Contri R, Valerio L, Lembo R, Pozzi L, Della Valle P, De Bonis M, Zangrillo A, Fiore GB, Redaelli A, Slepian MJ, Pappalardo F. Platelet activation is a preoperative risk factor for the development of thromboembolic complications in patients with continuous-flow left ventricular assist device. Eur J Heart Fail. 2018 Apr;20(4):792-800. doi: 10.1002/ejhf.1113.

- Consolo F, Sheriff J, Gorla S, Magri N, Bluestein D, Pappalardo F, Slepian MJ, Fiore GB, Redaelli A. High Frequency Components of Hemodynamic Shear Stress Profiles are a Major Determinant of Shear-Mediated Platelet Activation in Therapeutic Blood Recirculating Devices. Sci Rep. 2017 Jul 10;7(1):4994. doi: 10.1038/s41598-017-05130-5.

- Pietronave S, Zamperone A, Oltolina F, Colangelo D, Follenzi A, Novelli E, Diena M, Pavesi A, Consolo F, Fiore GB, Soncini M, Prat M. Monophasic and biphasic electrical stimulation induces a precardiac differentiation in progenitor cells isolated from human heart. Stem Cells Dev. 2014 Apr 15;23(8):888-98. doi: 10.1089/scd.2013.0375.

- Consolo F, Brizzola S, Tremolada G, Grieco V, Riva F, Acocella F, Fiore GB, Soncini M. A dynamic distention protocol for whole-organ bladder decellularization: histological and biomechanical characterization of the acellular matrix. J Tissue Eng Regen Med. 2016 Feb;10(2):E101-12. doi: 10.1002/term.1767.

- Consolo F, Bariani C, Mantalaris A, Montevecchi F, Redaelli A, Morbiducci U. Computational modeling for the optimization of a cardiogenic 3D bioprocess of encapsulated embryonic stem cells. Biomech Model Mechanobiol. 2012 Jan;11(1-2):261-77. doi: 10.1007/s10237-011-0308-0.

- Consolo F, Fiore GB, Truscello S, Caronna M, Morbiducci U, Montevecchi FM, Redaelli A. A computational model for the optimization of transport phenomena in a rotating hollow-fiber bioreactor for artificial liver. Tissue Eng Part C Methods. 2009 Mar;15(1):41-55. doi: 10.1089/ten.tec.2008.0213.

 

Selected Contributions in International Conferences

- Consolo F. Esposti F. Gustar A, Bertoldi L, De Bonis M, Pappalardo F. Loss of circadian rhythm in HVAD patients correlates with early diagnosis of pump thrombosis. 32nd European Association of Cardio-Thoracic Surgery (EACTS) Annual Meeting, 18-20 Oct, Milano, IT.

- Consolo F, Bozzi S, Sheriff J, Fiore GB, Bluestein D, Slepian MJ, Redaelli A. Advanced bioengineering approaches for the comprehensive analysis of the thrombogenic potential of frequency component elements of hemodynamic shear stress profiles relevant to cardiovascular implantable therapeutic devices. 8th World Congress of Biomechanics (WCB), 8-12 July 2018, Dublin, IRL.

- Consolo F, Dimasi A, Pieri M, De Bonis M, Rasponi M, Zangrilo A, Fiore GB, Slepian MJ, Pappalardo F, Redaelli A. Can we predict the thrombotic risk in patients with Left Ventricular Assist Device? 44th European Society for Artificial Organs (ESAO) and 7th International Federation for Artificial Organs (IFAO) Congress, 6-9 Sept, Vienna, AT.

- Consolo F, Sferrazza G, Pieri M, Zangrillo A, Redaelli A, Slepian MJ, Pappalardo F. The Platelet Activity State Assay Can Detect Shear-Mediated Platelet Activation Associated With Thrombosis In LVAD Patients. 2017 63rd ASAIO Annual Conference. June 21-24 2017. Chicago, IL (USA).

- Consolo F, Pozzi L, Motolone G, Sferrazza G, Pieri M, Della Valle P, Zangrillo A, Slepian MJ, D'Angelo A, Pappalardo F. Does Aspirin effectively inhibit Platelet Activation during Left Ventricular Assist Device support? 37th Annual Meeting and Scientific Sessions of the International Society for Heart and Lung Transplantation (ISHLT). April 5-8, 2017. San Diego, CA (USA).

- Dimasi A, Consolo F, Valerio L, Rasponi M, Phat LT, Redaelli A, Bluestein D, Slepian MJ. HyperShear in a Channel: A Microfluidic Facsimile of Mechanical Circulatory Support Devices to Reduce Thrombotic Risk and Enhance Patient Safety. NIH-IEEE 2015 Strategic Conference on Healthcare Innovations and Point-of-Care Technologies for Precision Medicine. 2015 November 9-10, NAID Conference Center, Bethesda, MD (USA).