Laboratories 2024/2025 - Cellular and Molecular Biology

Please find below the list of the Supervisors (with a link to their CV) and their PhD Projects proposed for the academic year 2024/2025 for the curriculum in Cellular and Molecular Biology.

The list includes the project based fellowships and below the free projects among which the candidates, who passed the first evaluation phase, must express their preference as indicated in the Call for Applications.

4 PROJECT-BASED FELLOWSHIPS:

Project-based fellowship CMB1: FOGGETTI GIORGIA

Unit: Lung Cancer Research Team, Experimental Oncology Division and Medical Oncology Department– IRCCS Ospedale San Raffaele

CMB1: Investigating mechanisms of drug resistance in EGFR-driven lung adenocarcinoma

Project-based fellowship CMB2: CIRILLO DANIELA

Unit: Emerging Bacterial Pathogens Unit – IRCCS Ospedale San Raffaele

CMB2: Improving the prediction of new regimens efficacy in drug resistant tuberculosis

Project-based fellowship CMB3: MACCHINI MARINA

Unit: Medical Oncology Unit – IRCCS Ospedale San Raffaele

Funded in the context of EU funds – NextGeneration EU- pursuant to DM 630/2024

CMB3: Analysis of antibody-drug conjugates efficacy in pancreatic adenocarcinoma models

Project-based fellowship CMB4: VENEREAU EMILIE

Unit: Tissue regeneration and homeostasis Unit – IRCCS Ospedale San Raffaele

Funded in the context of EU funds – NextGeneration EU- pursuant to DM 630/2024

CMB4: Preclinical Study of engineered HMGB1 proteins as Drug Candidates for Regenerative Medicine Applications

BOLETTA ALESSANDRA

Unit: Molecular basis of cystic kidney disorders

Refining the Molecular Mechanism of Glutamine Sensing by Primary Cilia

CENCI SIMONE

Unit: Age Related Diseases

ComBATaging: exploring the biological bases of the exceptional longevity of bats.

DE CURTIS IVAN

Unit: Cell adhesion

Project1: Assembly and regulation of plasma membrane-associated platforms during tumor cell motility Project2: Structure-function characterization of TANC2, a novel postsynaptic candidate associated to neuropsychiatric disorders

FRANCO IRENE

Unit: Molecular Genetics of Renal Disorders

Mechanisms of hypoxia-induced somatic mutation in pre-cancer kidneys

GABELLINI DAVIDE

Unit: Gene Expression Regulation

Project1: Characterization of DUX4-r leukemogenic mechanism Project2: Structure-function characterization of the DUX4-MATR3 complex Project3: A possible epigenetic therapy for FSHD muscular dystrophy

MANUNTA PAOLO

Unit: Genomics of Renal Diseases and Hypertension

Characterization of the Lss knock-in mouse model of salt-sensitive hypertension: unravelling novel pathways of organ damage associated with hypertension and aging

MAZZA DAVIDE

Unit: Imaging of Gene Regulation

The dynamic landscape of p53 interactions and their role in cancer cell fate determination

MILAN ENRICO

Unit: Age Related Diseases Laboratory

Dissecting TENT5-dependent Modulation of Protein Secretion

MUSCO GIOVANNA

Unit: Biomolecular NMR

Understanding the molecular details of DFL inhibition activity on HMGB1/CXCL12/CXCR4 axis

RAMPOLDI LUCA

Unit: Molecular Genetics of Renal Disorders

Project1: Role of uromodulin as a risk factor for hypertension and related kidney damage Project2: Dissecting the heterogeneous effects of renin mutations associated with Autosomal Dominant Tubulointerstitial Kidney Disease

SILVESTRI LAURA

Unit: Regulation of Iron Metabolism - Genetics and Cell Biology division

Deciphering the role of the BMP-SMAD signaling pathway modulator kielin/chordin-like protein (KCP) under physiological and pathological conditions

ZAMBRANO SAMUEL

Unit: Chromatin Dynamics

Role of macrophages NF-kB signaling dynamics in its interaction with tumor cells